Inflammatory Response and Antioxidants Status of Subjects with Diabetes Mellitus in Edo South Senatorial District of Nigeria

Christian Onosetale Ugege , Mathew Folaranmi Olaniyan , Caleb Akhere Aigbokhan , Edward Eghonghon Imadojemu , Teddy Ilenagbe

Oxidative Stress, Oxidative Markers, Redox Parameters, Diabetes Mellitus, Glutathione peroxidase (Gpx), Catalase (CAT), Malondialdehyde (MDA), Interelukin-10(IL-10), C-reactive protein(CRP).

Diabetes mellitus is marked by impaired glucose metabolism and a resultant effect of chronic hyperglycaemia. Type 2 diabetes also known as adult-onset diabetes is mainly caused by insulin resistance. The objective of this study is to determine inflammatory response and anti-oxidants function in diabetes mellitus in Edo South Senatorial district of Edo state. A total of 150 participants(100 subjects with diabetes mellitus and 50 apparently healthy individuals used as control) were recruited into this study. Participants were screened from Human immunodeficiency virus, hepatitis B, Hepatitis C and sputum acid alcohol fast bacili using enzyme linked immune-sorbent assay and gene xpert techniques respectively. Inflammatory response markers(interleukin 10 and C reactive protein), as well as oxidative stress markers; glutathione peroxidase, catalase and malondialdehyde were analyzed using chemiluminiscence techniques. The data were analysed using statistical software for social science version 23(International Business Machine, Chicago IL, USA). The mean value of C reactive protein in diabetic subjects were significantly higher than in controls(P=0.001), while a non-significant decrease in interleukin 10 was observed in diabetic group as compared to the controls. There was a significant increase in malondialdehyde in diabetic subjects as compared to their controls(P=0.014) while glutathione peroxidase and catalase experienced a significant decrease in diabetic group than the controls(P=0.000 and P=0.000 respectively). The relationship between assayed redox parameters depicted no significant correlation. Diabetic subjects display increased oxidative stress, indicated by elevated malondialdehyde levels and decreased antioxidant enzyme levels such as catalase and glutathione peroxidase. Accompanied by this induced oxidase stress is the concomitant inflammatory response marked by increase in the pro-inflammatory cytokine, C-reactive protein and a decrease in the levels of the anti-inflammatory cytokine, Interleukin-10 among diabetic patients

Published Paper   E-Certificate

"Inflammatory Response and Antioxidants Status of Subjects with Diabetes Mellitus in Edo South Senatorial District of Nigeria", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.a435-a445, September-2025, Available :https://ijsdr.org/papers/IJSDR2509050.pdf

Volume 10 Issue 9, September-2025

Pages : a435-a445

Paper Reg. ID: IJSDR_304837

Published Paper Id: IJSDR2509050

Downloads: 000117

Research Area: Humanities All

Country: Uzairue, Edo State, Edo State, Nigeria

Published Paper PDF: https://ijsdr.org/papers/IJSDR2509050

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2509050

DOI: https://doi.org/10.56975/ijsdr.v10i9.304837

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition