Drug Interaction Between Sartans and Pyridostigmine With a Focus on Hypoglycaemia: A Critical Review

Gudladona Raghava Ravali

drug interactions,pyridostigmine,hypoglycemia,ARB's,hypertension,Mayesthenia gravis

Sartans (angiotensin II receptor blockers, ARBs) and pyridostigmine are frequently prescribed drugs, each with well-established therapeutic roles. ARBs are widely used to manage hypertension, protect the cardiovascular system, and slow the progression of kidney disease, while pyridostigmine remains essential for conditions such as myasthenia gravis and autonomic dysfunction. Emerging evidence suggests that both classes of drugs can independently influence glucose metabolism. This review critically examines the global literature—including hospital case reports, pharmacovigilance signals, experimental studies, and mechanistic data—to evaluate their combined potential to precipitate hypoglycemia. Although no large clinical series directly document such events, mechanistic plausibility and scattered clinical reports highlight the need for caution, particularly in high‑risk patients. We also identify gaps in current knowledge and propose directions for future research.

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"Drug Interaction Between Sartans and Pyridostigmine With a Focus on Hypoglycaemia: A Critical Review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.10, Issue 9, page no.b731-b736, September-2025, Available :https://ijsdr.org/papers/IJSDR2509187.pdf

Volume 10 Issue 9, September-2025

Pages : b731-b736

Paper Reg. ID: IJSDR_305087

Published Paper Id: IJSDR2509187

Downloads: 00069

Research Area: Pharmacy All

Country: Banglore, Karnataka, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2509187

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2509187

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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