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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | INDOLE: A MULTIPOTENT NUCLEUS |
| Authors Name: | Shweta Singh , Amita Rana , Mahendra Rana |
| Unique Id: | IJSDR2309151 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | Indole (1H-indole) is one of the most important heterocyclic rings which offers a privileged scaffold in drug discovery. Indole derivatives have a vast pharmacological significance and provide a huge opportunity for discovering novel drugs with a different mode of action. The indole nucleus has shown its versatility and therapeutic potency in many naturally occurring compounds like alkaloids. In the recent past many studies have been conducted to integrate and explore various therapeutic aspects of this moiety. The indole scaffold found in both natural and synthetic sources is considered to be one of the most promising heterocyclic compounds possessing several biological activities viz. anticonvulsant, antidiabetic, anti-inflammatory, anti-HIV, anticancer, antitubercular, antioxidants, antihypertensive, antimicrobial, antifungal, etc. Indole derivatives have generated larger interest amongst various researchers to discover therapeutic leads to alleviate a large range of human ailments. In the present review, authors have reviewed and interpreted certain aspects and deciphered certain developments in the field of indole derivatives in the biological, chemical, and pharmacological paradigms of drug discovery including a few drug candidates currently under clinical trials |
| Keywords: | Indole, 1H-indole, Heterocyclic ring, Anticonvulsant, Antioxidants, Antidiabetic, Anti-inflammatory, Clinical trials. |
| Cite Article: | "INDOLE: A MULTIPOTENT NUCLEUS ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.1038 - 1055, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309151.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2309151 Registration ID:208640 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 1038 - 1055 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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