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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | COMPENDIOUS REVIEW ON ANIMAL MODELS AND SIGNALING PATHWAYS INVOLVED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS |
| Authors Name: | Selvakumar. S , Dr. P. Amudha , Esther Rani. E |
| Unique Id: | IJSDR2403036 |
| Published In: | Volume 9 Issue 3, March-2024 |
| Abstract: | Rheumatoid arthritis is an autoimmune disease that can lead to joint discomfort, swelling, and stiffness. It occurs when the immune system malfunctions and targets the synovium, the tissue that lines the joints. As a part of the innate immune response, macrophages produce TNF, IL-6, IL-1, GM-CSF, IL-15, IL-18, IL-32, and chemokines that induce tissue inflammation. The inflammatory synovium thickens, causing the joint area to feel sensitive and painful, appear red and swollen, and become more difficult to move. Occasionally, RA can also result in complications for the heart, circulatory system, eyes, and/or lungs. Rheumatoid arthritis (RA) experimental models have made a significant contribution to our knowledge of the etiology and management of this inflammatory disease. Furthermore, a range of transgenic and genetically engineered knockout mice are available to analyze intricate disease processes. This is a big step forward for arthritis translational research. The current review will be focusing on improving knowledge of the experimental arthritis models in rodents and pathophysiology of RA based on the signaling pathways involved. |
| Keywords: | Keywords: RA, Chemokines, GM-CSF, transgenic model, signaling pathways. |
| Cite Article: | "COMPENDIOUS REVIEW ON ANIMAL MODELS AND SIGNALING PATHWAYS INVOLVED IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.225 - 231, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403036.pdf |
| Downloads: | 000337362 |
| Publication Details: | Published Paper ID: IJSDR2403036 Registration ID:210319 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: 225 - 231 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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