Formulation and evaluation of multi-particulate system to enhance formulation efficacy

Shobhit K.Suralke , Dr. Bhushan S. Bhoyar

Multiparticulate system, Immediate Release, Sustained Release, Drug Delivery System.

Multiparticulate is an advanced drug delivery method that offers several features for the successful development of immediate-release and controlled-release formulations. To enhance the effectiveness of a formulation, multilayer formulations are repeatedly used to avoid chemical incompatibilities between the active pharmaceutical components and to make it possible to produce various dose forms with distinct drug release patterns. The pharmaceutical industry has shown substantial interest in the manufacture of multiparticulate dosage forms by the increasing compaction of loose powder layers. Multiparticulate dosage forms are suitable for the simultaneous delivery of two medications in succession, the segregation of two incompatible chemicals, and the development of a continuous release in a single layer of immediate release as the initial dose and the second layer as the ongoing dose. The quick-release layer of the multiparticulate acted as an initial dose, while the sustained-release layer maintained therapeutic levels of the medication in the bloodstream for a prolonged duration. To address common GI problems such as low yield, cross-contamination between layers, insufficient hardness, improper individual layer weight control, and layer separation, high-quality multiparticulate development, and production need to be carried out on polymer presses specifically designed for that use. Using a modified polymer layer may be the best way to make multi particulate dosage under GMP conditions, especially when a lot of dosage needs to be made.

Published Paper   E-Certificate

"Formulation and evaluation of multi-particulate system to enhance formulation efficacy", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.482 - 489, February-2024, Available :https://ijsdr.org/papers/IJSDR2402073.pdf

Volume 9 Issue 2, February-2024

Pages : 482 - 489

Paper Reg. ID: IJSDR_210151

Published Paper Id: IJSDR2402073

Downloads: 000347351

Research Area: Pharmacy

Country: Amravati, maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2402073

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2402073

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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