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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and evaluation of multi-particulate system to enhance formulation efficacy |
| Authors Name: | Shobhit K.Suralke , Dr. Bhushan S. Bhoyar |
| Unique Id: | IJSDR2402073 |
| Published In: | Volume 9 Issue 2, February-2024 |
| Abstract: | Multiparticulate is an advanced drug delivery method that offers several features for the successful development of immediate-release and controlled-release formulations. To enhance the effectiveness of a formulation, multilayer formulations are repeatedly used to avoid chemical incompatibilities between the active pharmaceutical components and to make it possible to produce various dose forms with distinct drug release patterns. The pharmaceutical industry has shown substantial interest in the manufacture of multiparticulate dosage forms by the increasing compaction of loose powder layers. Multiparticulate dosage forms are suitable for the simultaneous delivery of two medications in succession, the segregation of two incompatible chemicals, and the development of a continuous release in a single layer of immediate release as the initial dose and the second layer as the ongoing dose. The quick-release layer of the multiparticulate acted as an initial dose, while the sustained-release layer maintained therapeutic levels of the medication in the bloodstream for a prolonged duration. To address common GI problems such as low yield, cross-contamination between layers, insufficient hardness, improper individual layer weight control, and layer separation, high-quality multiparticulate development, and production need to be carried out on polymer presses specifically designed for that use. Using a modified polymer layer may be the best way to make multi particulate dosage under GMP conditions, especially when a lot of dosage needs to be made. |
| Keywords: | Multiparticulate system, Immediate Release, Sustained Release, Drug Delivery System. |
| Cite Article: | "Formulation and evaluation of multi-particulate system to enhance formulation efficacy", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 2, page no.482 - 489, February-2024, Available :http://www.ijsdr.org/papers/IJSDR2402073.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2402073 Registration ID:210151 Published In: Volume 9 Issue 2, February-2024 DOI (Digital Object Identifier): Page No: 482 - 489 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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